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The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells.双重GLP-1和GIP受体激动剂替尔泊肽与β-肾上腺素能受体产生意外相互作用,并在高血糖或衰老心肌细胞的葡萄糖代谢中发挥作用。
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Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease.靶向药物递送策略:通向糖尿病肾病治疗的桥梁。
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GLP-1 Receptor Agonists in Diabetic Kidney Disease.

作者信息

Michos Erin D, Tuttle Katherine R

机构信息

Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Providence Medical Research Center, Providence Health Care, Spokane, Washington.

出版信息

Clin J Am Soc Nephrol. 2021 Oct;16(10):1578-1580. doi: 10.2215/CJN.18771220. Epub 2021 Apr 13.

DOI:10.2215/CJN.18771220
PMID:33849933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8499005/
Abstract
摘要