Cousins Justine, Czachowski Michael, Muthukrishnan Ashok, Currie Geoff
Community College of Allegheny County, Pittsburgh, Pennsylvania.
Department of Nuclear Medicine and Molecular Imaging, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
J Nucl Med Technol. 2017 Jun;45(2):82-86. doi: 10.2967/jnmt.116.187385. Epub 2017 Mar 9.
Brown adipose tissue (BAT) has been widely reported to affect the efficacy of F-FDG PET in oncology. Several small studies have found that warming the patient both before F-FDG injection and during the uptake phase can reduce the frequency of BAT uptake. Pharmaceutical approaches such as propranolol and diazepam have also been used. We describe two case studies that demonstrated the impact of combined patient warming and diazepam administration on BAT uptake in pediatric F-FDG PET images. To support these findings, we performed a retrospective analysis of 139 patients: 71 who received warming only and 68 who received warming combined with diazepam. BAT uptake was significantly less frequent in patients who received diazepam (16.2%) than in those who did not (33.8%) ( = 0.0167), particularly in female patients (7.4% vs. 26.7%) ( = 0.0486). Although patient warming alone reduces the frequency of BAT uptake, the addition of diazepam to patient warming significantly furthers the reduction in young patients, particularly female patients.
棕色脂肪组织（BAT）对肿瘤学中F-FDG PET的效能影响已被广泛报道。几项小型研究发现，在注射F-FDG之前以及摄取阶段对患者进行升温，可以降低BAT摄取的频率。也使用了诸如普萘洛尔和地西泮等药物方法。我们描述了两个病例研究，其证明了在儿科F-FDG PET图像中，联合患者升温与地西泮给药对BAT摄取的影响。为支持这些发现，我们对139例患者进行了回顾性分析：71例仅接受升温，68例接受升温并联合地西泮。接受地西泮的患者中BAT摄取频率（16.2%）显著低于未接受地西泮的患者（33.8%）（P = 0.0167），尤其是女性患者（7.4%对26.7%）（P = 0.0486）。虽然仅患者升温就能降低BAT摄取频率，但在患者升温基础上加用地西泮可显著进一步降低年轻患者尤其是女性患者的BAT摄取频率。
