Verhagen W I, Renier W O, ter Laak H, Jaspar H H, Gabreels F J
Department of Child Neurology, St. Radboud University Hospital, Nijmegen, The Netherlands.
Epilepsia. 1988 Jan-Feb;29(1):57-62. doi: 10.1111/j.1528-1157.1988.tb05099.x.
Morphological and biochemical findings are described from the brain biopsy of an 11-year-old girl with intractable type II epilepsia partialis continua. Computerized tomography scan showed severe progressive central and cortical atrophy, mainly of the right hemisphere. Brain biopsy revealed microangiopathy of the cortex-penetrating arteries, patchy necrosis of the cortex, and small loose infiltrates of lymphocytic cells. Biochemical analysis showed normal pyruvate metabolism and citric acid cycle in gray and white matter.
描述了一名患有难治性II型持续性部分性癫痫的11岁女孩脑活检的形态学和生化检查结果。计算机断层扫描显示严重的进行性中枢和皮质萎缩，主要发生在右半球。脑活检显示皮质穿透动脉微血管病变、皮质斑片状坏死以及淋巴细胞的小片状疏松浸润。生化分析显示灰质和白质中丙酮酸代谢和柠檬酸循环正常。
