Kasian Anastasiya, Kolomin Timur, Andreeva Lyudmila, Bondarenko Elena, Myasoedov Nikolay, Slominsky Petr, Shadrina Maria
Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Behav Neurol. 2017;2017:5091027. doi: 10.1155/2017/5091027. Epub 2017 Feb 9.
It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.
结果表明，塞尔坦的抗焦虑作用与经典苯二氮䓬类药物相当，且它们的作用机制可能相似。这些数据表明，塞尔坦的存在可能会改变经典苯二氮䓬类药物的作用。为了验证这一假设，我们在不可预测的慢性轻度应激条件下以及无此应激条件下，通过高架十字迷宫试验，评估了塞尔坦和地西泮单独及联合给药后对大鼠的抗焦虑活性。我们发现，即使在没有慢性应激的情况下，给予一个疗程的受试物质会使焦虑指标朝着恶化的方向变化，但给予一个疗程的塞尔坦后的变化不太明显。在慢性应激条件下，同时使用地西泮和塞尔坦后的焦虑指标值与慢性应激暴露前观察到的相应值没有差异。所获得的数据表明，单独给予塞尔坦在降低因给予一个疗程的受试物质而升高的焦虑水平方面最有效，而地西泮与塞尔坦联合使用在降低不可预测的慢性轻度应激条件下的焦虑方面最有效。
