Kozlovskiĭ I I, Andreeva L A, Kozlovskaia M M, Nadorova A V, Kolik L G
Eksp Klin Farmakol. 2012;75(2):10-3.
Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test. Naloxone (1.0 mg/kg, i.p.) per se evoked swift runaway in OF peripheral areas in BALB/C mice while "freezing" the reaction in C57BL/6 mice with active response to stress under the same conditions. Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice. The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.
在纳洛酮急性给药后阿片系统活性降低的情况下，对具有高焦虑水平和低焦虑水平、在旷场试验中具有被动和主动情绪应激反应表型的BALB/C和C57BL/6近交系小鼠，研究了硒兰克（塔夫辛七肽类似物）抗焦虑作用的特点。硒兰克（0.25毫克/千克，腹腔注射）本身通过增加总体运动活动在BALB/C小鼠中表现出抗焦虑作用，在旷场试验中对C57BL/6小鼠的行为无影响。纳洛酮（1.0毫克/千克，腹腔注射）本身在相同条件下使BALB/C小鼠在旷场周边区域迅速逃窜，而使对压力有主动反应的C57BL/6小鼠的反应“冻结”。用纳洛酮预处理减弱了BALB/C小鼠对硒兰克的敏感性，而C57BL/6小鼠对该肽抗焦虑作用的反应增强。所获得的数据揭示了硒兰克在中枢神经系统中的一个新靶点，并表明脑啡肽 - 阿片系统活性在个体对硒兰克的敏感性中的重要性。
