Jacobs J W, Vlasuk G P, Rosenblatt M
Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania.
Endocrinol Metab Clin North Am. 1987 Mar;16(1):63-77.
All of the actions of atrial natriuretic factor (ANF) can be explained on the basis of ANF's interaction with specific receptors on the plasma membrane of cells in target tissues. These receptors have been identified. Binding to these receptors by ANF is time dependent and specific and occurs with high affinity. Numerous analogues of ANF have been synthesized, and in general, their affinity for ANF receptors corresponds closely to their potency in vitro and in vivo. Considerable progress has been made in physicochemically characterizing ANF receptors by photoaffinity labeling and affinity cross-linking techniques.
心房利钠因子（ANF）的所有作用都可以基于其与靶组织细胞质膜上特定受体的相互作用来解释。这些受体已被识别。ANF与这些受体的结合具有时间依赖性和特异性，并且以高亲和力发生。已经合成了许多ANF类似物，一般来说，它们对ANF受体的亲和力与它们在体外和体内的效力密切相关。通过光亲和标记和亲和交联技术在对ANF受体进行物理化学表征方面已经取得了相当大的进展。
