Deckert J, Estall L B, Marangos P J, Cooper S J
Unit on Neurochemistry, NIMH, Bethesda, MD 20892.
Eur J Pharmacol. 1987 Oct 27;142(3):457-60. doi: 10.1016/0014-2999(87)90088-4.
Central- and peripheral-type benzodiazepine receptors were analyzed in several brain areas of rats (n = 8-9) that had been treated for five days with CGS 8216 (20 mg/kg per day). Twenty-four hours after cessation of drug treatment a significant decrease of central-type benzodiazepine receptors as labeled by [3H]beta-carboline-3-carboxylate ethyl ester ([3H]beta CCE) and [3H]flunitrazepam ([3H]FNZ), but not of peripheral-type benzodiazepine receptors as labeled by [3H]RO 5-4864 could be observed in the animals treated with CGS 8216.
对用CGS 8216（每天20毫克/千克）治疗5天的大鼠（n = 8 - 9）的几个脑区中的中枢型和外周型苯二氮䓬受体进行了分析。在停止药物治疗24小时后，在用CGS 8216治疗的动物中，可观察到用[3H]β-咔啉-3-羧酸乙酯（[3H]βCCE）和[3H]氟硝西泮（[3H]FNZ）标记的中枢型苯二氮䓬受体显著减少，但用[3H]RO 5-4864标记的外周型苯二氮䓬受体未减少。
