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Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.

作者信息

Morrow A L, Suzdak P D, Paul S M

机构信息

Section on Molecular Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Eur J Pharmacol. 1987 Oct 27;142(3):483-5. doi: 10.1016/0014-2999(87)90094-x.

DOI:10.1016/0014-2999(87)90094-x
PMID:2828079
Abstract
摘要

相似文献

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Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.类固醇激素代谢产物以纳摩尔效力增强γ-氨基丁酸（GABA）受体介导的氯离子通量。
Eur J Pharmacol. 1987 Oct 27;142(3):483-5. doi: 10.1016/0014-2999(87)90094-x.
2
Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes.3α-羟基类固醇的合成、代谢及药理活性，这些类固醇可增强大鼠大脑皮质突触神经小体中γ-氨基丁酸（GABA）受体介导的氯离子摄取。
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Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain.
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gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel.γ-氨基丁酸（GABA）和巴比妥酸盐介导的大鼠脑突触神经小体对³⁶Cl⁻的摄取：GABA受体偶联氯离子通道快速脱敏的证据
Mol Pharmacol. 1986 Nov;30(5):419-26.
5
Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.苯二氮䓬、巴比妥酸盐、乙醇及催眠性甾体激素对大鼠脑突触神经小体中γ-氨基丁酸介导的氯离子转运的调节作用
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6
Responses of gamma-aminobutyrate receptor from rat brain: similarity of different preparation methods; muscimol induced desensitization and chloride exchange.大鼠脑γ-氨基丁酸受体的反应：不同制备方法的相似性；蝇蕈醇诱导的脱敏作用和氯离子交换
J Membr Biol. 1989 Nov;111(3):229-40. doi: 10.1007/BF01871008.
7
Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.类固醇与γ-氨基丁酸受体门控氯离子通道相互作用的表征：多个类固醇识别位点的证据。
Mol Pharmacol. 1990 Feb;37(2):263-70.
8
Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.类固醇麻醉剂和天然存在的类似物在一个与巴比妥类药物不同的位点调节γ-氨基丁酸受体复合物。
J Pharmacol Exp Ther. 1989 Mar;248(3):960-6.
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Phaclofen antagonizes GABA at autoreceptors regulating release in rat cerebral cortex.
Eur J Pharmacol. 1988 Sep 13;154(2):223-4. doi: 10.1016/0014-2999(88)90104-5.
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Effects of GABA antagonists, SR 95531 and bicuculline, on GABAA receptor-regulated chloride flux in rat cortical synaptoneurosomes.γ-氨基丁酸拮抗剂SR 95531和荷包牡丹碱对大鼠皮质突触神经小体中γ-氨基丁酸A受体调节的氯离子通量的影响。
Neurochem Res. 1990 Sep;15(9):905-10. doi: 10.1007/BF00965910.

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