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Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.

作者信息

Morrow A L, Suzdak P D, Paul S M

机构信息

Section on Molecular Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Adv Biochem Psychopharmacol. 1988;45:247-61.

PMID:2902744
Abstract
摘要

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1
Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.苯二氮䓬、巴比妥酸盐、乙醇及催眠性甾体激素对大鼠脑突触神经小体中γ-氨基丁酸介导的氯离子转运的调节作用
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GABA-stimulated 36Cl- flux in brain slices as an assay for modulation by CNS depressant drugs.以脑片中外加γ-氨基丁酸(GABA)刺激的36Cl-通量作为中枢神经系统抑制药物调节作用的一种检测方法。
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Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.类固醇激素代谢产物以纳摩尔效力增强γ-氨基丁酸(GABA)受体介导的氯离子通量。
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[Role of benzodiazepine receptors in realizing the anxiolytic effect of compounds on intact rats and on animals with a physical dependence ethanol].[苯二氮䓬受体在实现化合物对完整大鼠和有乙醇身体依赖性动物的抗焦虑作用中的作用]
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Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal.乙醇戒断期间大鼠γ-氨基丁酸A受体对神经活性甾体的敏化作用。
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Biochemical properties of the GABA/barbiturate/benzodiazepine receptor-chloride ion channel complex.
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