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研究苦西瓜果肉对链脲佐菌素诱导的糖尿病雄性大鼠睾丸和附睾氧化应激的影响。

Investigating the effects of Citrullus colocynthis pulp on oxidative stress in testes and epididymis in streptozotocin-induced diabetic male rats.

作者信息

Ostovan Fereshteh, Gol Ali, Javadi Abdolreza

机构信息

Faculty of Science, Payam noor University, Iranshhar, Iran.

Department of Biology, Faculty of Science, University of Shahid Bahonar, Kerman, Iran.

出版信息

Int J Reprod Biomed. 2017 Jan;15(1):41-48.

PMID:28280799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5340138/
Abstract

BACKGROUND

Diabetes mellitus is one of the most common metabolic diseases in humans, affecting 100 million people around the world.

OBJECTIVE

Investigating the effects of Citrullus colocynthis pulp on oxidant and antioxidant factors of testes and epididymis in streptozotocin-induced diabetic male rats.

MATERIALS AND METHODS

Thirty two male rats were divided into four groups (n=8) 1) N (normal) group, 2) N+C group, 3) D (diabetic) group and 4) D+C group. Groups N and D received normal saline 2 ml orally for two weeks and groups N+C and D+C received 10 mg/kg.bw Citrullus colocynthis pulp orally for two weeks. Diabetes was induced by single intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg.

RESULTS

D group had a significant increase in HO (Hydrogen peroxide) and MDA (malondialdehyde) concentrations, and CAT (catalase) activity, and also a significant decrease in Peroxidase (POD) activity compared to N group. D+C group had a significant decrease in HO and MDA concentrations and, CAT activity and significant increase in POD activity compared to D group.

CONCLUSION

Citrullus colocynthis pulp in two weeks had beneficial effects on oxidants and antioxidants changes in reproductive system in streptozotocin-induced diabetic rats.

摘要

背景

糖尿病是人类最常见的代谢疾病之一，全球有1亿人受其影响。

目的

研究苦西瓜果肉对链脲佐菌素诱导的糖尿病雄性大鼠睾丸和附睾氧化及抗氧化因子的影响。

材料与方法

32只雄性大鼠分为四组（n = 8）：1）N（正常）组，2）N + C组，3）D（糖尿病）组和4）D + C组。N组和D组口服2 ml生理盐水，持续两周；N + C组和D + C组口服10 mg/kg体重的苦西瓜果肉，持续两周。通过腹腔注射65 mg/kg链脲佐菌素（STZ）诱导糖尿病。

结果

与N组相比，D组过氧化氢（HO）和丙二醛（MDA）浓度显著升高，过氧化氢酶（CAT）活性显著升高，而过氧化物酶（POD）活性显著降低。与D组相比，D + C组HO和MDA浓度显著降低，CAT活性显著降低，POD活性显著升高。

结论

苦西瓜果肉在两周内对链脲佐菌素诱导的糖尿病大鼠生殖系统的氧化和抗氧化变化具有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/fe1ac2fa5bce/ijrb-15-041-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/fc0fe6043ef3/ijrb-15-041-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/8bf33c180370/ijrb-15-041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/69cfb52e7717/ijrb-15-041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/6a89f5535e56/ijrb-15-041-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/5bab7c6b1f04/ijrb-15-041-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/a477ce23a00d/ijrb-15-041-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/fe1ac2fa5bce/ijrb-15-041-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/fc0fe6043ef3/ijrb-15-041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/6ec303c37f54/ijrb-15-041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/66cf01cd90e6/ijrb-15-041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/8bf33c180370/ijrb-15-041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/69cfb52e7717/ijrb-15-041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/6a89f5535e56/ijrb-15-041-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/5bab7c6b1f04/ijrb-15-041-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/a477ce23a00d/ijrb-15-041-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/5340138/fe1ac2fa5bce/ijrb-15-041-g009.jpg

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The Diabetic Lung Can Be Ameliorated by by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes.通过减轻1型糖尿病大鼠的炎症和氧化应激可改善糖尿病肺。 （注：原英文句子中多了一个by，正确句子应该是The Diabetic Lung Can Be Ameliorated by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes. ）
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