通过减轻1型糖尿病大鼠的炎症和氧化应激可改善糖尿病肺。 （注：原英文句子中多了一个by，正确句子应该是The Diabetic Lung Can Be Ameliorated by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes. ）
The Diabetic Lung Can Be Ameliorated by by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes.
作者信息
Bejeshk Mohammad Abbas, Bagheri Fatemeh, Salimi Fouzieh, Rajizadeh Mohammad Amin
机构信息
Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Evid Based Complement Alternat Med. 2023 Jul 21;2023:5176645. doi: 10.1155/2023/5176645. eCollection 2023.
BACKGROUND
Diabetes impacts various organs in the body and some reports showed that the lung is also affected by diabetes, and an imbalance of inflammation and oxidative stress may participate to diabetic lung impairments. The present study is conducted to assess the impacts of (CC) on some aspects of these impairments.
METHODS
Frothy two male Wistar rats (3-4 months old and weighing 200-250 g) were used in the present research. Animals were divided into 3 groups of control, Diabetes, and Diabetes + Drug. CC was administered to diabetic rats orally. The lung tissue and BALF oxidative stress and inflammatory indices including the MDA, TAC, SOD, Gpx, TNF, IL-6, IL-17, and IL-10 were evaluated by the ELISA method.
RESULTS
Our observations disclosed the ameliorative impacts of CC administration against oxidative stress and inflammation imbalance. Also, it was found that CC improved body weight and fasting blood sugar in rats with diabetes.
CONCLUSION
We can conclude that the administration of CC can be effective in improving diabetic lungs in rats.
背景
糖尿病会影响身体的各个器官，一些报告显示肺部也会受到糖尿病的影响，炎症和氧化应激的失衡可能参与糖尿病性肺损伤。本研究旨在评估（CC）对这些损伤某些方面的影响。
方法
本研究使用了两只雄性Wistar大鼠（3 - 4个月大，体重200 - 250克）。动物被分为对照组、糖尿病组和糖尿病+药物组。CC经口服给予糖尿病大鼠。通过ELISA法评估肺组织和支气管肺泡灌洗液（BALF）的氧化应激和炎症指标，包括丙二醛（MDA）、总抗氧化能力（TAC）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（Gpx）、肿瘤坏死因子（TNF）、白细胞介素-6（IL-6）、白细胞介素-17（IL-17）和白细胞介素-10（IL-10）。
结果
我们的观察结果揭示了给予CC对氧化应激和炎症失衡的改善作用。此外，还发现CC改善了糖尿病大鼠的体重和空腹血糖。
结论
我们可以得出结论，给予CC可有效改善大鼠的糖尿病性肺损伤。
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