Gouin Jean-Philippe, Caldwell Warren, Woods Robbie, Malarkey William B
Department of Psychology, Concordia University, Montreal, Canada.
PERFORM Center, Concordia University, 7141 Sherbrooke Street West, PY 170-14, Montreal, QC, H4B 1R6, Canada.
Ann Behav Med. 2017 Oct;51(5):782-786. doi: 10.1007/s12160-017-9891-3.
Exposure to adverse childhood experiences (ACE) has been associated with elevated circulating inflammatory markers in adulthood. Despite the robust effect of ACE on later health outcomes, not all individuals exposed to ACE suffer from poor health.
The goal of this study was to evaluate whether current resilience resources may attenuate the impact of ACE on inflammatory markers among individuals with elevated C-reactive protein (CRP) levels.
Participants (N = 174) completed one-time self-report questionnaires assessing ACE exposure within the first 18 years of life and current resilience resources, and provided blood samples for interleukin-6 (IL-6) and CRP.
Individuals who were exposed to multiple ACE had greater IL-6 than participants with lesser ACE exposure. However, current resilience resources significantly moderated this effect. Among individuals who reported multiple ACE, higher resilience resources were associated with lower IL-6 levels.
These data suggest that resilience resources might attenuate the association between ACE and later health outcomes.
童年不良经历（ACE）与成年后循环炎症标志物升高有关。尽管ACE对后期健康结果有显著影响，但并非所有经历过ACE的个体健康状况都不佳。
本研究的目的是评估当前的复原力资源是否可以减轻ACE对C反应蛋白（CRP）水平升高的个体炎症标志物的影响。
参与者（N = 174）完成一次性自我报告问卷，评估18岁之前的ACE暴露情况和当前的复原力资源，并提供血液样本用于检测白细胞介素-6（IL-6）和CRP。
暴露于多种ACE的个体比暴露于较少ACE的参与者有更高的IL-6水平。然而，当前的复原力资源显著调节了这种效应。在报告有多种ACE的个体中，较高的复原力资源与较低的IL-6水平相关。
这些数据表明，复原力资源可能会减弱ACE与后期健康结果之间的关联。
