Elliot Ari J, Chapman Benjamin P
Department of Psychiatry, University of Rochester.
Health Psychol. 2016 Nov;35(11):1205-1213. doi: 10.1037/hea0000392. Epub 2016 Jun 9.
Our objective was to investigate interactions of psychological resources and socioeconomic status (SES)-as well as potential gender differences and the explanatory role of childhood and adult stress exposures, health behaviors, and negative and positive affect-in predicting markers of systemic inflammation.
We utilized a sample of adults from the Midlife Development in the U.S. (MIDUS) study who provided biomarker data (N = 1,152). SES was operationalized as a composite of education, income, and occupational prestige, and the psychological resources construct was operationalized as a latent factor measured with optimism, perceived control, and self-esteem. Linear regression models examined these 2 factors and their interaction in predicting interleukin-6 (IL-6) and C-reactive protein (CRP) measured on average 2 years later, as well as 3-way interactions involving gender and the impact of covariate adjustment.
Psychological resources interacted with SES in men (for IL-6: p < .001; for CRP: p = .04) but not in women. In men, greater psychological resources was associated with lower concentrations of IL-6 at lower levels of SES but higher concentrations of both markers at higher levels of SES. The inverse association between resources and IL-6 at low SES was moderately attenuated upon adjustment for negative affect.
Socioeconomic status might modulate the linkage between psychological resources and systemic inflammation in men. At lower levels of SES, resources may be related to lower inflammation in part through lower negative affect. Associations with higher inflammation at higher SES add to growing evidence suggesting that adaptive psychological characteristics may be associated with markers of poorer physiological function under certain conditions. (PsycINFO Database Record
我们的目的是研究心理资源与社会经济地位（SES）之间的相互作用，以及潜在的性别差异，以及童年和成年期应激暴露、健康行为、消极和积极情绪在预测全身炎症标志物方面的解释作用。
我们使用了来自美国中年发展（MIDUS）研究的成年人样本，他们提供了生物标志物数据（N = 1152）。SES被定义为教育、收入和职业声望的综合指标，心理资源结构被定义为一个潜在因素，通过乐观、感知控制和自尊来衡量。线性回归模型检验了这两个因素及其相互作用对平均两年后测量的白细胞介素-6（IL-6）和C反应蛋白（CRP）的预测作用，以及涉及性别的三向相互作用和协变量调整的影响。
心理资源与SES在男性中存在相互作用（对于IL-6：p <.001；对于CRP：p =.04），但在女性中不存在。在男性中，较低SES水平下，更多的心理资源与较低的IL-6浓度相关，但在较高SES水平下，两种标志物的浓度都较高。在调整消极情绪后，低SES水平下资源与IL-6之间的负相关有所减弱。
社会经济地位可能调节男性心理资源与全身炎症之间的联系。在较低的SES水平下，资源可能部分通过较低的消极情绪与较低的炎症相关。在较高SES水平下与较高炎症的关联进一步证明，在某些情况下，适应性心理特征可能与较差生理功能的标志物相关。（PsycINFO数据库记录）
