Ze Eun Young, Kim Beom Jin, Kang Hyun, Kim Jae Gyu
Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Dig Dis Sci. 2017 May;62(5):1265-1271. doi: 10.1007/s10620-017-4467-4. Epub 2017 Mar 9.
To investigate the association between abdominal fat distribution represented by the visceral fat area (VFA) to subcutaneous fat area (SFA) ratio, and erosive esophagitis (EE).
Seven hundred and twenty-eight participants aged >40 years underwent physical examination, blood tests, esophagogastroduodenoscopy, and abdominal computer tomography at Chung-Ang University Hospital from 2007 to 2012.
Of 728 subjects, 65 (8.9%) had EE. The EE patients had higher body mass index, metabolic syndrome prevalence, triglyceride levels, and blood pressure (P < 0.05). The mean VFA/SFA ratio was higher in the EE group than in the non-EE group (1.30 vs. 0.92, P < 0.001). The predominance of EE in the group with higher VFA/SFA ratio was higher than in the group with lower VFA/SFA ratio (P < 0.001). A VFA/SFA ratio ≥1.165 had good accuracy to predict EE (area under the receiver-operating characteristic curve, 0.643). The VFA/SFA ratio and visceral fat volume were positively correlated with the severity of EE (P = 0.002), and a VFA/SFA ratio ≥1.165 was strongly correlated with the severity of EE (P < 0.001).
The high VFA/SFA ratio can be a useful clinical predictor of EE.
探讨以内脏脂肪面积（VFA）与皮下脂肪面积（SFA）之比表示的腹部脂肪分布与糜烂性食管炎（EE）之间的关联。
2007年至2012年，728名年龄大于40岁的参与者在中央大学医院接受了体格检查、血液检查、食管胃十二指肠镜检查和腹部计算机断层扫描。
在728名受试者中，65名（8.9%）患有EE。EE患者的体重指数、代谢综合征患病率、甘油三酯水平和血压更高（P<0.05）。EE组的平均VFA/SFA比值高于非EE组（1.30对0.92，P<0.001）。VFA/SFA比值较高组的EE患病率高于VFA/SFA比值较低组（P<0.001）。VFA/SFA比值≥1.165对预测EE具有良好的准确性（受试者工作特征曲线下面积，0.643）。VFA/SFA比值和内脏脂肪体积与EE的严重程度呈正相关（P=0.002），VFA/SFA比值≥1.165与EE的严重程度密切相关（P<0.001）。
高VFA/SFA比值可能是EE的一个有用的临床预测指标。
