Department of Cardiology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Sci Rep. 2017 Mar 10;7:44003. doi: 10.1038/srep44003.
The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recurrence after catheter ablation. A total of 502 consecutive patients with AF who underwent catheter ablation were included. AF recurrence was defined as a documented episode of any atrial arrhythmias lasting ≥30 s after a blanking period of 3 months. AF recurrence was observed between 3 and 12 months after catheter ablation in 24.5% of the patients. There was a significant difference in the allele distribution (p = 7.86 × 10) and genotype distribution (p = 1.42 × 10) of rs6795970 between the AF recurrence and no recurrence groups. In a multivariate analysis, we identified the following independent predictors of AF recurrence: the rs6795970 genotypes in an additive model (OR 0.36, 95%CI 0.220.60, p = 7.04 × 10), a history of AF ≥36 months (OR 3.57, 95%CI 2.265.63, p = 4.33 × 10) and left atrial diameter (LAD) ≥40 mm (OR 1.85, 95%CI 1.08~3.19, p = 0.026). These data suggest that genetic variation in SCN10A may play an important role in predicting AF recurrence after catheter ablation in the Chinese Han population.
SCN10A 上的非同义单核苷酸多态性（SNP）rs6795970 已被报道与 PR 间期和心房颤动（AF）相关，并且与 AF 相关的 SNP rs6800541 呈强烈连锁不平衡（LD）。在这项研究中，我们研究了 rs6795970 多态性是否与导管消融后 AF 的复发相关。共纳入 502 例连续接受导管消融的 AF 患者。AF 复发定义为空白期 3 个月后记录到任何持续 ≥30s 的心房心律失常事件。消融后 3 至 12 个月内，24.5%的患者出现 AF 复发。AF 复发组和无复发组 rs6795970 的等位基因分布（p=7.86×10）和基因型分布（p=1.42×10）存在显著差异。多变量分析显示，rs6795970 的以下基因型是 AF 复发的独立预测因素：加性模型中的基因型（OR 0.36，95%CI 0.220.60，p=7.04×10）、AF 病史≥36 个月（OR 3.57，95%CI 2.265.63，p=4.33×10）和左心房直径（LAD）≥40mm（OR 1.85，95%CI 1.08~3.19，p=0.026）。这些数据表明，SCN10A 中的遗传变异可能在预测汉族人群导管消融后 AF 的复发中起重要作用。
