Dominguez-Lopez Pablo, Diaz-Cueto Laura, Arechavaleta-Velasco Miguel, Caldiño-Soto Felipe, Ulloa-Aguirre Alfredo, Arechavaleta-Velasco Fabian
a Unidad de Investigacion Medica en Medicina Reproductiva, UMAE Hospital de Gineco Obstetricia No. 4 Luis Castelazo Ayala, Instituto Mexicano del Seguro Social , Ciudad de Mexico , Mexico.
b Centro Nacional de Investigacion Disciplinaria en Fisiologia y Mejoramiento Animal, Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias , Queretaro , Mexico.
J Matern Fetal Neonatal Med. 2018 Mar;31(5):580-585. doi: 10.1080/14767058.2017.1292245. Epub 2017 Feb 28.
Recently, a study based on the analysis of accelerated evolution of related genes at birth identified the follicle-stimulating hormone receptor (FSHR) as a possible candidate for the development of preterm delivery. Additionally, FSHR expression has been described in extragonadal tissue including the placenta. Therefore, the aim of the present study was to determine the association between the N680S polymorphism of the follicle-stimulating hormone receptor and preterm birth in a population of Hispanic women.
Placenta samples were obtained from 64 women who had preterm births and 54 control cases. DNA was extracted and genotyped for the N680S FSHR gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism. The χ test and t-test were used to calculate statistical significance.
Statistically significant differences in genotype frequencies for the N680S polymorphism were observed between preterm and term groups (p = .04). Based on the Akaike information criterion values, the dominant model showed that the NN genotype had a significantly increased risk of preterm birth compared with the SS + NS genotype (OR 2.52, 95% CI 1.20-5.33, p = .02).
The results herein suggest that the FSHR polymorphism N680S is significantly associated with preterm birth in the Hispanic population.
最近，一项基于出生时相关基因加速进化分析的研究确定促卵泡激素受体（FSHR）可能是早产发生的一个候选因素。此外，FSHR在包括胎盘在内的性腺外组织中也有表达。因此，本研究的目的是确定西班牙裔女性群体中促卵泡激素受体N680S多态性与早产之间的关联。
从64例早产女性和54例对照病例中获取胎盘样本。通过聚合酶链反应-限制性片段长度多态性对DNA进行提取并对FSHR基因N680S多态性进行基因分型。采用χ检验和t检验计算统计学意义。
早产组和足月组之间N680S多态性的基因型频率存在统计学显著差异（p = 0.04）。基于赤池信息准则值，显性模型显示与SS + NS基因型相比，NN基因型早产风险显著增加（OR 2.52，95% CI 1.20 - 5.33，p = 0.02）。
本文结果表明，FSHR多态性N680S与西班牙裔人群的早产显著相关。
