Kim Hee Jin, Cho Hanna, Werring David J, Jang Young Kyoung, Kim Yeo Jin, Lee Jin San, Lee Juyoun, Jun Soomin, Park Seongbeom, Ryu Young Hoon, Choi Jae Yong, Cho Young Seok, Moon Seung Hwan, Na Duk L, Lyoo Chul Hyoung, Seo Sang Won
Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Neuroscience Center, Samsung Medical Center, Seoul, Korea.
J Alzheimers Dis. 2017;57(3):711-716. doi: 10.3233/JAD-161139.
Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11C-Pittsburgh Compound B (PiB) PET or 18F-florbetaben PET to evaluate amyloid burden, and 18F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.
淀粉样β蛋白在脑血管中的沉积，即脑淀粉样血管病（CAA），与脑叶出血、脑微出血和皮质浅表性铁沉积的MRI表现相关。尽管病理研究表明tau可能与血管淀粉样蛋白共定位，但尚未在活体CAA中对此进行研究。三名可能患有CAA的患者接受了11C-匹兹堡化合物B（PiB）PET或18F-氟贝他班PET以评估淀粉样蛋白负荷，并接受了18F-AV-1451 PET以评估双螺旋丝tau蛋白负荷。出现脑微出血或皮质浅表性铁沉积的区域与显示18F-AV-1451增加的区域大部分重叠。我们的初步研究提出了一种可能性，即作为血管淀粉样蛋白特征性标志物的脑叶脑微出血和皮质浅表性铁沉积可能与双螺旋丝tau蛋白的局部产生有关。
