Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ann Neurol. 2010 Oct;68(4):545-8. doi: 10.1002/ana.22099.
Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.
高级脑血管β-淀粉样蛋白沉积（脑淀粉样血管病，CAA）与脑微出血有关，但 CAA 负担与微出血的确切关系尚未明确。我们使用 T2*-加权磁共振成像（MRI）和匹兹堡化合物 B（PiB）的无创性淀粉样蛋白成像来分析 CAA 和微出血之间的空间关系。在配准的正电子发射断层扫描（PET）和 MRI 图像上，与模拟对照病变相比，微出血部位的 PiB 保留增加（p = 0.002），并且随着与微出血距离的增加而下降（p < 0.0001）。这些发现表明微出血优先发生在集中淀粉样蛋白的局部区域，并支持旨在减少血管淀粉样蛋白沉积的治疗策略。
