University of Oulu, Optoelectronics and Measurement Techniques Research Unit, Health & Wellness Measurements Group, Oulu, Finland.
Leibniz Institute for Neurobiology, Magdeburg, Germany.
Sci Rep. 2017 Mar 14;7(1):172. doi: 10.1038/s41598-017-00293-7.
Studies with magnetoencephalography (MEG) are still quite rarely combined simultaneously with methods that can provide a metabolic dimension to MEG investigations. In addition, continuous blood pressure measurements which comply with MEG compatibility requirements are lacking. For instance, by combining methods reflecting neurovascular status one could obtain more information on low frequency fluctuations that have recently gained increasing interest as a mediator of functional connectivity within brain networks. This paper presents a multimodal brain imaging setup, capable to non-invasively and continuously measure cerebral hemodynamic, cardiorespiratory and blood pressure oscillations simultaneously with MEG. In the setup, all methods apart from MEG rely on the use of fibre optics. In particular, we present a method for measuring of blood pressure and cardiorespiratory oscillations continuously with MEG. The potential of this type of multimodal setup for brain research is demonstrated by our preliminary studies on human, showing effects of mild hypercapnia, gathered simultaneously with the presented modalities.
使用脑磁图（MEG）的研究仍然相当罕见，同时结合能够为 MEG 研究提供代谢层面的方法。此外，还缺乏符合 MEG 兼容性要求的连续血压测量。例如，通过结合反映神经血管状态的方法，人们可以获得更多关于低频波动的信息，这些波动最近作为脑网络功能连接的中介而引起了越来越多的关注。本文提出了一种多模态脑成像设置，能够非侵入性地连续测量脑血流动力学、心肺和血压波动，同时进行 MEG 测量。在该设置中，除了 MEG 之外的所有方法都依赖于光纤的使用。特别是，我们提出了一种连续测量血压和心肺波动的方法，与 MEG 一起使用。通过我们在人类身上进行的初步研究，展示了这种多模态设置在脑研究中的潜力，同时收集了所呈现模态的轻度高碳酸血症的影响。
