转运蛋白揭秘。
Transporters Revealed.
机构信息
Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
出版信息
Cell. 2017 Mar 9;168(6):951-953. doi: 10.1016/j.cell.2017.02.033.
The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.
亚家族 C 三磷酸腺苷结合盒（ABC）转运蛋白介导多药耐药和离子电导调节。使用单颗粒冷冻电子显微镜（cryo-EM）测定的三种生理相关 ABC 转运蛋白（MRP1、SUR1 和 CFTR）的亚家族的原子或近原子分辨率结构揭示了有助于解释该 ABC 转运蛋白亚家族广泛功能多样性的结构细节。
Zotero 插件