Hasan Hayder, Attlee Amita, Raigangar Veena, Madkour Mohamed, Awadallah Samir
College of Health Sciences, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
College of Health Sciences, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S337-S341. doi: 10.1016/j.dsx.2017.03.012. Epub 2017 Mar 6.
Occurrence of metabolic syndrome (MetS) in the United Arab Emirates (UAE) is rising steadily, with subsequent increase in the prevalence of type 2 diabetes and cardiovascular disease (CVD). Recent studies have shown that PCSK9 plays a substantial role in atherogenic dyslipidemia. Hence, the aim of this study was to assess level of PCSK9 and its relationship with MetS components among young adult females.
This study was carried out on 137 adult females over 18 years of age residing in the UAE. Subjects were categorized into two groups according to waist circumferences (WC): normal (<80cm; n=41) and large (≥80cm; n=96). Anthropometric and biochemical parameters in the fasting state (glucose, insulin, lipid profile, and PCSK9) were determined using conventional techniques. Homeostasis model assessment of insulin resistance (HOMA-IR) and MetS scores were calculated as appropriate.
PCSK9 was lower in subjects with large WC compared to normal WC (p=0.016). PCSK9 correlated negatively with measures of obesity (p<0.05), and positively with IR (r=0.425, p<0.001). Multiple linear regression analysis revealed that the strongest predictor of PCSK9 was IR (B=6.213; p<0.001), followed by WC (B=-2.488; p<0.001) and triglycerides (B=0.897; p=0.013).
Results from this study demonstrate that PCSK9 correlates with some components of metabolic syndrome and central obesity in young females. Such findings support the suggestion of using PCSK9 inhibitors in the management of MetS to modify risk for development of CVD.
阿拉伯联合酋长国（阿联酋）代谢综合征（MetS）的发生率正在稳步上升，随之而来的是2型糖尿病和心血管疾病（CVD）患病率的增加。最近的研究表明，前蛋白转化酶枯草溶菌素9（PCSK9）在致动脉粥样硬化性血脂异常中起重要作用。因此，本研究的目的是评估年轻成年女性中PCSK9的水平及其与MetS各组分的关系。
本研究对居住在阿联酋的137名18岁以上成年女性进行。根据腰围（WC）将受试者分为两组：正常组（<80cm；n = 41）和大腰围组（≥80cm；n = 96）。使用传统技术测定空腹状态下的人体测量和生化参数（血糖、胰岛素、血脂谱和PCSK9）。适当计算胰岛素抵抗的稳态模型评估（HOMA-IR）和MetS评分。
与正常WC受试者相比，大WC受试者的PCSK9水平较低（p = 0.016）。PCSK9与肥胖指标呈负相关（p < 0.05），与胰岛素抵抗呈正相关（r = 0.425，p < 0.001）。多元线性回归分析显示，PCSK9的最强预测因子是胰岛素抵抗（B = 6.213；p < 0.001），其次是WC（B = -2.488；p < 0.001）和甘油三酯（B = 0.897；p = 0.013）。
本研究结果表明，PCSK9与年轻女性代谢综合征的某些组分及中心性肥胖相关。这些发现支持了使用PCSK9抑制剂来管理MetS以改变CVD发生风险的建议。
