Wohlrab J, Michael J
Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland.
An-Institut für angewandte Dermatopharmazie e. V., Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.
Hautarzt. 2017 Jun;68(6):478-482. doi: 10.1007/s00105-017-3963-y.
Various hair-related diseases, systemic dermatoses as well as parasitic diseases are treated via topical application of active substances. The density of hair follicles and the consequential special conditions for diffusion require specific galenic concepts that can vary considerably depending on the respective therapeutic purpose. Both the physicochemical properties of the active ingredient and the nature of the application area must be considered when choosing an appropriate galenic base. Highly relevant here are hairiness, scarring, hyperkeratosis and exoserosis. Low-viscosity bases and foams are often preferred because of their good spreadability. Packages with nozzle tip or comb-shaped dispensers are user-friendly and can significantly enhance patient adherence to topical treatment.
各种与头发相关的疾病、全身性皮肤病以及寄生虫病都可通过局部应用活性物质来治疗。毛囊的密度以及随之而来的特殊扩散条件需要特定的药剂学概念,这些概念会因各自的治疗目的而有很大差异。在选择合适的药剂学基质时,必须考虑活性成分的物理化学性质以及应用部位的性质。多毛症、瘢痕形成、角化过度和表皮脱落在这里高度相关。低粘度基质和泡沫通常因其良好的铺展性而更受青睐。带有喷嘴或梳状 dispenser 的包装使用方便,可显著提高患者对局部治疗的依从性。 (注:“dispenser”常见释义为“分配器”,这里结合语境灵活翻译为“涂抹器”之类更合适的表述会更好,但按要求未做调整)