Araújo Lidiane Advincula de, Addor Flavia, Campos Patrícia Maria Berardo Gonçalves Maia
Universidade de São Paulo (USP) - Ribeirão Preto (SP), Brazil.
Private clinic - São Pulo (SP), Brazil.
An Bras Dermatol. 2016 May-Jun;91(3):331-5. doi: 10.1590/abd1806-4841.20163986.
Silicon is the second most abundant element on Earth, and the third most abundant trace element in human body. It is present in water, plant and animal sources. On the skin, it is suggested that silicon is important for optimal collagen synthesis and activation of hydroxylating enzymes, improving skin strength and elasticity. Regarding hair benefits, it was suggested that a higher silicon content in the hair results in a lower rate of hair loss and increased brightness. For these beneficial effects, there is growing interest in scientific studies evaluating the efficacy and safety of using dietary supplements containing silicon. Its use aims at increasing blood levels of this element and improving the skin and its annexes appearance. There are different forms of silicon supplements available and the most important consideration to be made in order to select the best option is related to safety and bioavailability. Silicon supplements are widely used, though there is wide variation in silicon bioavailability, ranging from values below 1% up to values close to 50%, depending on the chemical form. Therefore, the aim of this study was to evaluate the scientific literature related to the different chemical forms of silicon supplements available and the limitations and recent progress in this field. According to reported studies, among the different chemical forms available, the orthosilicic acid (OSA) presents the higher bioavailability, whereas the others forms have absorption inversely proportional to the degree of polymerization. However, clinical studies evaluating safety and efficacy are still lacking.
硅是地球上第二丰富的元素,也是人体中第三丰富的微量元素。它存在于水、植物和动物来源中。在皮肤上,硅对于最佳的胶原蛋白合成和羟化酶的激活很重要,可提高皮肤强度和弹性。关于对头发的益处,有人认为头发中较高的硅含量会导致较低的脱发率并增加光泽度。鉴于这些有益效果,科学研究对评估含硅膳食补充剂的功效和安全性的兴趣日益浓厚。其用途旨在提高该元素的血液水平并改善皮肤及其附属器的外观。有不同形式的硅补充剂可供选择,为选择最佳选项而需要考虑的最重要因素与安全性和生物利用度有关。硅补充剂被广泛使用,尽管硅的生物利用度差异很大,根据化学形式的不同,其范围从低于1%到接近50%不等。因此,本研究的目的是评估与现有硅补充剂的不同化学形式相关的科学文献以及该领域的局限性和最新进展。根据已报道的研究,在现有的不同化学形式中,原硅酸(OSA)具有更高的生物利用度,而其他形式的吸收与聚合程度成反比。然而,仍缺乏评估安全性和有效性的临床研究。