Carter E A, Kirkham S E, Udall J N, Jung W, Walker W A
Department of Pediatrics, Harvard Medical School, Boston, MA.
J Burn Care Rehabil. 1986 Nov-Dec;7(6):475-8. doi: 10.1097/00004630-198611000-00005.
Following acute thermal injury to rats produced by scalding water, there was marked elevation of a number of plasma enzyme activities, including GOT, GPT, and 5'-nucleotidase, suggesting hepatic dysfunction. Changes in plasma enzyme activities were observed within minutes following application of acute burn trauma, and remained elevated for at least one month. The magnitude of the elevations of the plasma enzyme activities was dependent upon the length of time the acute burn trauma was applied to the skin and/or the percentage of skin surface area burned. These changes in plasma enzyme activity correlated with histologic examination of the hepatic tissue, indicating single cell necrosis. These data suggest that acute burn trauma to rats is associated with altered hepatic function.
用热水烫伤大鼠造成急性热损伤后，包括谷草转氨酶、谷丙转氨酶和5'-核苷酸酶在内的多种血浆酶活性显著升高，提示肝功能障碍。急性烧伤创伤后数分钟内即可观察到血浆酶活性的变化，且至少持续升高一个月。血浆酶活性升高的幅度取决于急性烧伤创伤施加于皮肤的时间长度和/或皮肤表面积烧伤的百分比。血浆酶活性的这些变化与肝组织的组织学检查相关，表明存在单细胞坏死。这些数据表明，大鼠急性烧伤创伤与肝功能改变有关。
