Wang Xiaolin, Huang Dehui, Huang Xusheng, Zhang Jiatang, Ran Ye, Lou Xin, Gui Qiuping, Yu Shengyuan
The PLA General Hospital, Department of Neurology, PR China.
The PLA General Hospital, Department of Radiology, PR China.
J Neuroimmunol. 2017 Apr 15;305:68-71. doi: 10.1016/j.jneuroim.2017.01.014. Epub 2017 Jan 26.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroid (CLIPPERS) was first described in 2010. The characteristic clinical picture, radiological distribution and steroid response have been well-described in previous reports. However, the underlying pathogenesis and nosological position of CLIPPERS in the CNS require further investigation for the primary CNS lymphoma have been identified by autopsy subsequently. Here, we report a 51-year-old woman who was diagnosed with CLIPPERS but progressed to primary CNS lymphomatoid granulomatosis, which supports that CLIPPERS is not just an inflammatory CNS disorder.
类固醇反应性桥脑周围血管强化的慢性淋巴细胞性炎症（CLIPPERS）于2010年首次被描述。其特征性临床表现、放射学分布及类固醇反应在既往报告中已有详细描述。然而，CLIPPERS在中枢神经系统中的潜在发病机制和疾病分类位置仍需进一步研究，因为随后经尸检发现了原发性中枢神经系统淋巴瘤。在此，我们报告一名51岁女性，其最初被诊断为CLIPPERS，但随后进展为原发性中枢神经系统淋巴瘤样肉芽肿病，这支持CLIPPERS不仅仅是一种中枢神经系统炎性疾病。
