从枸骨叶中分离得到的三种新三萜类化合物及其对过氧化氢诱导的心肌细胞损伤的保护作用。
Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against HO-induced myocardial cell injury.
作者信息
Li Shan-Shan, Liu Yan-Li, Xu Qiong-Ming, Mao Chen-Mei, Yang Shi-Lin
机构信息
Children's Hospital of Soochow University, Suzhou 215003, China; College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
出版信息
Chin J Nat Med. 2017 Feb;15(2):115-120. doi: 10.1016/S1875-5364(17)30027-4.
In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against HO-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity.
在本研究中，从枸骨的地上部分分离得到了三种新的三萜类化合物，即23-羟基乌苏-12,18-二烯-28-酸3β-O-α-L-阿拉伯吡喃糖苷（1）、23-羟基乌苏-12,18-二烯-28-酸3β-O-β-D-葡萄糖醛酸吡喃糖苷-6-O-甲酯（2）和乌苏-12,18-二烯-28-酸3β-O-β-D-葡萄糖醛酸吡喃糖苷-6-O-甲酯（3），以及一种已知的三萜类化合物3β-羟基乌苏-2,18-二烯-28-酸（4，randialic acid B）。通过光谱分析（红外光谱、电喷雾电离质谱、高分辨电喷雾电离质谱以及一维和二维核磁共振）和化学反应确定了它们的结构。化合物4对过氧化氢诱导的H9c2心肌细胞损伤显示出显著的细胞保护作用。化合物1-4均未表现出任何显著的二苯基苦味酰基自由基清除活性。
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