Wu Yuwei, Zhang Baihui, Li Wenxian, Peng Lihua, Qiao Weilin, Li Wei, Guo De-An
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, People's Republic of China.
Nat Prod Bioprospect. 2025 Mar 13;15(1):18. doi: 10.1007/s13659-025-00499-7.
Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (1-9) and one oleanane-type glycoside (10), along with seven known compounds (11-17). Compound 1 is the first reported 19,22-epoxy ursane triterpenoid glycoside, whereas 4 and 5 are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group. The structural characterization of these compounds was achieved using spectroscopic and chemical techniques, as well as single-crystal X-ray analysis. Compounds 7, 12, 15, and 17 exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.
对毛冬青正丁醇提取物的植物化学研究发现了10种新的五环三萜糖苷，包括9种乌苏烷型糖苷（1-9）和1种齐墩果烷型糖苷（10），以及7种已知化合物（11-17）。化合物1是首次报道的19,22-环氧乌苏烷三萜糖苷，而化合物4和5是含有28,19-内酯基团的乌苏烷三萜糖苷的罕见例子。这些化合物的结构表征通过光谱和化学技术以及单晶X射线分析得以实现。化合物7、12、15和17对H1975和HCC827癌细胞表现出中等细胞毒性活性。
Zotero 插件
