Neisius D, Wood J M
Biological Research Department, Ciba-Geigy Limited, Basle, Switzerland.
J Hypertens. 1987 Dec;5(6):721-5. doi: 10.1097/00004872-198712000-00015.
Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 weeks after ligation, respectively; n = 9). There was a small increase in plasma renin activity (PRA) after 2 weeks, but PRA decreased thereafter and there was no correlation between PRA and BP. The renin inhibitor CGP 29,287 (Ciba-Geigy Ltd., Basle, Switzerland, synthesized by D.B. Rinker and P. Bühlmayer; 1 mg/kg i.p.) and the angiotensin converting enzyme (ACE) inhibitor, enalaprilat (Merck Sharp and Dohme, USA.; 2 mg/kg i.p.), lowered the BP of the hypertensive marmosets to normotensive levels. These results indicate that although PRA is not elevated in this primate model of hypertension, BP is dependent on the activity of the renin-angiotensin system.
通过结扎一侧肾动脉的小分支在狨猴中诱导高血压。采用尾袖法测量血压（BP），血压在4 - 5周内升至高血压水平，最大升高出现在4 - 15周后（结扎前和结扎后10周的BP，均值±标准误分别为120±3和152±6 mmHg；n = 9）。2周后血浆肾素活性（PRA）有小幅升高，但此后PRA下降，且PRA与BP之间无相关性。肾素抑制剂CGP 29,287（瑞士巴塞尔的汽巴 - 嘉基有限公司，由D.B. Rinker和P. Bühlmayer合成；腹腔注射1 mg/kg）和血管紧张素转换酶（ACE）抑制剂依那普利拉（美国默克夏普&多贺公司；腹腔注射2 mg/kg）可将高血压狨猴的血压降至正常血压水平。这些结果表明，尽管在该高血压灵长类动物模型中PRA未升高，但血压依赖于肾素 - 血管紧张素系统的活性。
