Wood J M, Gulati N, Michel J B, Hofbauer K G
J Hypertens. 1986 Apr;4(2):251-4. doi: 10.1097/00004872-198604000-00017.
The purpose of this study was to assess whether two-kidney, one clip (2K1C) renal hypertension can be induced in the marmoset. During the first 3-5 weeks after renal arterial clipping, blood pressure (BP) and plasma renin activity (PRA) increased in approximately one-third of the operated marmosets. However, within 10 weeks after clipping, BP and PRA had returned to control values. There was a significant positive correlation between BP and log PRA 3 and 5 weeks after the operation, but no correlation was observed at 10 weeks. In a selected group of marmosets with the highest values of BP (greater than 140 mmHg; n = 4), the converting enzyme inhibitor, enalapril (2 mg/kg s.c.) lowered BP by 58 +/- 7 (s.e.m.) mmHg when given 3 weeks after clipping. At 18 weeks the response to enalapril was only -17 +/- 6 mmHg. These results demonstrate that unilateral renal arterial clipping in marmosets results in a transient renin-dependent hypertension. Marmosets in this initial hypertensive phase could be useful for investigating the antihypertensive effects of inhibitors of human renin.
本研究的目的是评估在狨猴中能否诱发两肾一夹（2K1C）肾性高血压。在肾动脉夹闭后的最初3至5周内，约三分之一接受手术的狨猴血压（BP）和血浆肾素活性（PRA）升高。然而，夹闭后10周内，BP和PRA已恢复至对照值。术后3周和5周时，BP与log PRA之间存在显著正相关，但在10周时未观察到相关性。在一组选定的血压值最高（大于140 mmHg；n = 4）的狨猴中，夹闭3周后给予转化酶抑制剂依那普利（2 mg/kg皮下注射）可使血压降低58±7（标准误）mmHg。在18周时，对依那普利的反应仅为-17±6 mmHg。这些结果表明，狨猴单侧肾动脉夹闭会导致短暂的肾素依赖性高血压。处于这个初始高血压阶段的狨猴可能有助于研究人肾素抑制剂的降压作用。
