Bora Emre, Özerdem Ayşegül
Dokuz Eylül University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
Dokuz Eylül University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey; Dokuz Eylul University, Health Sciences Institute, Department of Neurosciences, Izmir, Turkey.
Eur Neuropsychopharmacol. 2017 Apr;27(4):293-300. doi: 10.1016/j.euroneuro.2017.02.009. Epub 2017 Mar 8.
Cognitive impairment is evident euthymic patients with bipolar disorder (BP) and in their first-degree relatives (BP-Rel). Increasing evidence suggests that BP is also associated with social cognitive impairment. It is important to establish whether social cognitive impairment is also evident in BP-Rel. A novel meta-analysis of theory of mind (ToM) and facial emotion recognition in BP-Rel including 16 studies (728 first-degree relatives of patients with BP and 865 healthy controls) was conducted. ToM (d=0.34, CI=0.16-0.52) was significantly impaired in BP-Rel. The effect size for the difference between BP-Rel and healthy controls was smaller for facial emotion recognition (d=0.17, CI=0.16-0.29) and could be nonsignificant after the effect of publication bias was taken into account. First-degree relatives of patients with BP underperform healthy subjects in social cognitive abilities, particularly in ToM. However, the effect size for between-group difference is small. ToM impairment might be a vulnerability marker of BP.
双相情感障碍（BP）的心境正常患者及其一级亲属（BP-Rel）存在认知障碍。越来越多的证据表明，双相情感障碍也与社会认知障碍有关。确定社会认知障碍在BP-Rel中是否也很明显很重要。对BP-Rel中的心理理论（ToM）和面部情绪识别进行了一项新的荟萃分析，包括16项研究（728名双相情感障碍患者的一级亲属和865名健康对照）。BP-Rel中的ToM（d=0.34，CI=0.16-0.52）明显受损。BP-Rel与健康对照之间差异的效应大小在面部情绪识别方面较小（d=0.17，CI=0.16-0.29），考虑发表偏倚的影响后可能不显著。双相情感障碍患者的一级亲属在社会认知能力方面表现不如健康受试者，尤其是在心理理论方面。然而，组间差异的效应大小较小。心理理论受损可能是双相情感障碍的一个易感性标志物。
