Bipolar Disorders Program, Department of Psychiatry, Neuroscience Institute, Favaloro University, Buenos Aires, Argentina.
Psychiatry Res. 2011 Oct 30;189(3):379-84. doi: 10.1016/j.psychres.2011.04.033. Epub 2011 May 28.
The main aim of this study was to compare patients with euthymic bipolar I (BDI) and bipolar II (BDII) disorders and healthy controls in measures of social cognition. Additional aims were to explore the association between social cognition performance with neurocognitive impairments and psychosocial functioning. Eighty one euthymic patients with BDI or BDII and 34 healthy controls were included. All subjects completed tests to assess verbal memory, attention, and executive functions. Additionally theory of mind (ToM) and facial emotion recognition measures were included. Psychosocial functioning was assessed with the GAF. Both groups of patients had lower performance than healthy controls in ToM, and a lower recognition of fear facial expression. When neurocognitive impairments and exposure to medications were controlled, performance in ToM and recognition of fear facial expression did not allow predicting if a subject was patient or healthy control. Social cognition measures not enhance variance beyond explained by neurocognitive impairments and they were not independent predictors of psychosocial functioning. Impairments in facial emotion recognition and ToM are mediated, at least partly, by attention-executive functions deficits and exposure to psychotropic medications. Likewise, social cognition measures did not contribute to variance beyond neurocognitive impairments.
本研究的主要目的是比较处于缓解期的双相情感障碍 I 型（BDI）和双相情感障碍 II 型（BDII）患者与健康对照组在社会认知方面的差异。此外，还探索了社会认知表现与神经认知障碍和心理社会功能之间的关系。共有 81 名处于缓解期的 BDI 或 BDII 患者和 34 名健康对照组纳入研究。所有受试者均完成了测试，以评估言语记忆、注意力和执行功能。此外，还包括心理理论（ToM）和面部情绪识别测试。使用 GAF 评估心理社会功能。与健康对照组相比，两组患者在 ToM 和恐惧面部表情识别方面的表现均较差。当控制神经认知障碍和药物暴露后，ToM 和恐惧面部表情识别的表现并不能预测受试者是患者还是健康对照组。社会认知测试并不能增加神经认知障碍解释的方差，也不是心理社会功能的独立预测因素。面部情绪识别和心理理论的损伤至少部分是由注意力-执行功能缺陷和精神药物暴露引起的。同样，社会认知测试并不能增加神经认知障碍解释的方差。
