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医院病原体耐甲氧西林金黄色葡萄球菌(MRSA)基因分型的当前方法。

Current methodologies on genotyping for nosocomial pathogen methicillin-resistant Staphylococcus aureus (MRSA).

作者信息

Miao Jian, Chen Lequn, Wang Jingwen, Wang Wenxin, Chen Dingqiang, Li Lin, Li Bing, Deng Yang, Xu Zhenbo

机构信息

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, PR China.

Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, PR China.

出版信息

Microb Pathog. 2017 Jun;107:17-28. doi: 10.1016/j.micpath.2017.03.010. Epub 2017 Mar 9.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen in hospitals and the community. As the rapid spread and wide distribution of antimicrobial resistance (such as MRSA), treatment for infectious diseases caused by microorganisms has become a vital threat. Thus, early identification and genotyping are essential for further therapeutic treatment and the control of rapid expansion of MRSA. In combination with applications and data feedbacks, this review focused on the currently available molecular-based assays on their utility and performance for rapid typing of MRSA, especially on effective molecular-based methods. Besides, a common mobile element SCCmec and prevalence of HA-MRSA, LA-MRSA and CA-MRSA were introduced in this review in order to provide a more complete profile of MRSA.

摘要

耐甲氧西林金黄色葡萄球菌(MRSA)是医院和社区中的常见病原体。随着抗菌药物耐药性(如MRSA)的迅速传播和广泛分布,由微生物引起的传染病治疗已成为重大威胁。因此,早期鉴定和基因分型对于进一步的治疗以及控制MRSA的快速传播至关重要。结合应用和数据反馈,本综述重点关注当前可用基于分子的检测方法在MRSA快速分型方面的效用和性能,特别是有效的基于分子的方法。此外,本综述还介绍了常见的移动元件SCCmec以及医院获得性MRSA(HA-MRSA)、家畜源性MRSA(LA-MRSA)和社区获得性MRSA(CA-MRSA)的流行情况,以便更全面地了解MRSA。

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