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TRPA1: Acrolein meets its target.

作者信息

Achanta Satyanarayana, Jordt Sven-Eric

机构信息

Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, United States.

Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, United States; Yale Tobacco Center of Regulatory Science (TCORS), Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, United States.

出版信息

Toxicol Appl Pharmacol. 2017 Jun 1;324:45-50. doi: 10.1016/j.taap.2017.03.007. Epub 2017 Mar 8.

Abstract
摘要

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Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.
PLoS One. 2016 Nov 3;11(11):e0165200. doi: 10.1371/journal.pone.0165200. eCollection 2016.
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TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein.
Toxicol Appl Pharmacol. 2017 Jun 1;324:51-60. doi: 10.1016/j.taap.2016.10.008. Epub 2016 Oct 13.
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Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein.
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Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx.
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