Kim Hyungsup, Kim Minwoo, Jang Yongwoo
Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Department of Medical and Digital Engineering, College of Engineering, Hanyang University, Seoul 04736, Republic of Korea.
Biomol Ther (Seoul). 2024 Mar 1;32(2):192-204. doi: 10.4062/biomolther.2023.118. Epub 2023 Aug 8.
Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca-permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.
一般来说，气味分子由嗅觉受体检测，嗅觉受体是在嗅觉神经元中表达的特殊化学感受器。除了气味分子外，某些挥发性分子可通过呼吸道吸入，这常常导致身体发生病理生理变化。这些吸入的分子通过激活外周组织中钙通透性瞬时受体电位（TRP）通道来介导细胞信号传导。本综述全面概述了参与检测挥发性分子并对其作出反应的TRP通道，这些挥发性分子包括有害物质、麻醉剂、植物衍生化合物和信息素。该综述旨在阐明吸入挥发性分子感知背后的生物学机制。因此，本综述将有助于更好地理解TRP通道在对吸入分子反应中的作用，为其对人类健康和疾病的影响提供见解。
