双重免疫同时抑制 HIV-1 进展。

Dual Immunity Concomitantly Suppresses HIV-1 Progression.

机构信息

Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Department of Biotechnology, Faridabad, Haryana 121001, India.

Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Department of Biotechnology, Faridabad, Haryana 121001, India; International AIDS Vaccine Initiative, New York, NY, USA.

出版信息

Trends Microbiol. 2017 May;25(5):334-335. doi: 10.1016/j.tim.2017.02.011. Epub 2017 Mar 8.

DOI:10.1016/j.tim.2017.02.011

PMID:28284876

Abstract

Broadly neutralizing antibodies (bnAbs) elicited in HIV-1 elite neutralizers typically are unable to reduce viremia in the same individuals from whom they are isolated. A recent study reports the development of bnAbs in an elite controller that, along with the help of T cells, were associated with restricting HIV-1 progression.

摘要

广谱中和抗体（bnAbs）在 HIV-1 精英中和者中被诱导产生，但通常无法降低从其分离的个体的病毒血症。最近的一项研究报告了在一名精英控制者中发展广谱中和抗体的情况，这些抗体与 T 细胞一起，与限制 HIV-1 进展有关。