Ross D, Vohra J, Cole P, Hunt D, Sloman G
Aust N Z J Med. 1978 Aug;8(4):377-83. doi: 10.1111/j.1445-5994.1978.tb04905.x.
The electrophysiological effects of an intravenous dose of disopyramide phosphate (2 mg per kg body weight) were studied in 17 patients. Studies were performed with the patients fasting, unpremedicated, and off all medication for three days. Blood samples for estimation of serum levels of disopyramide were collected in 15 of these patients. The effects of intravenous disopyramide were maximal at five minutes, less marked at 20 minutes, and largely gone by 30 minutes after administration of the drug. Sinus cycle length and corrected sinus node recovery time were shortened significantly. No index of atrioventricular nodal function was significantly changed. Both atrial and ventricular effective refractory periods were significantly prolonged. Further impairment of intraventricular conduction occurred in six patients with bundle branch block on electrocardiogram or prolonged HV interval. In one of two patients with Wolff-Parkinson-White syndrome, the bypass effective refractory period was prolonged. These electrophysiological changes are similar to quinidine and quinidine like drugs. It is recommended that disopyramide should be used cautiously in patients with evidence of His Purkinje system disease since it may lead to higher degrees of intraventricular block.
对17例患者研究了静脉注射磷酸丙吡胺（2mg/kg体重）的电生理效应。研究在患者禁食、未用术前药且停药三天的情况下进行。其中15例患者采集了血样以测定血清丙吡胺水平。静脉注射丙吡胺的效应在给药后5分钟时最大，20分钟时减弱，30分钟时基本消失。窦性周期长度和校正的窦房结恢复时间显著缩短。房室结功能指标无显著变化。心房和心室有效不应期均显著延长。心电图有束支传导阻滞或HV间期延长的6例患者发生了室内传导的进一步损害。在两例预激综合征患者中，有一例旁路有效不应期延长。这些电生理变化与奎尼丁及类奎尼丁药物相似。建议对有希氏束-浦肯野系统疾病证据的患者谨慎使用丙吡胺，因为它可能导致更高程度的室内传导阻滞。
