丙吡胺对心房及房室传导和不应期的双重作用。
Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.
作者信息
Birkhead J S, Vaughan Williams E M
出版信息
Br Heart J. 1977 Jun;39(6):657-60. doi: 10.1136/hrt.39.6.657.
Abstract
Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.
摘要
在胆碱能阻滞的情况下，已表明丙吡胺对窦房结自律性和心房不应期有抑制作用。它还可延长房室传导并增加房室不应期。这些效应在体内常被该药的抗胆碱能效应所掩盖。
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