Al-Saadi S A, Gross P, Wildy P
Department of Pathology, University of Cambridge, U.K.
J Gen Virol. 1988 Feb;69 ( Pt 2):433-8. doi: 10.1099/0022-1317-69-2-433.
Herpes simplex virus type 2 has been reactivated from the latent state in the footpad and dorsal root ganglia of acycloguanosine-treated BALB/c mice. Virus was also recovered from the footpad tissue but not from the ganglia of denervated, latently infected mice. Treatment in vitro of explanted footpad cultures with acycloguanosine or phosphonoacetic acid did not affect the rate of virus reactivation. In all the isolates examined the virus was found to be acycloguanosine-sensitive. Recovery of virus from footpad tissue of mice after a long period of acycloguanosine treatment supports the theory that virus had been truly latent in the footpad and not in a state of persistent infection.
在接受无环鸟苷治疗的BALB/c小鼠的足垫和背根神经节中，单纯疱疹病毒2型已从潜伏状态重新激活。病毒也从足垫组织中分离出来，但未从去神经支配的潜伏感染小鼠的神经节中分离出来。用无环鸟苷或膦甲酸对体外培养的足垫组织进行处理，并不影响病毒重新激活的速率。在所有检测的分离株中，发现病毒对无环鸟苷敏感。经过长时间无环鸟苷治疗后从小鼠足垫组织中分离出病毒，支持了病毒在足垫中处于真正潜伏状态而非持续感染状态的理论。
