McLennan J L, Darby G
J Gen Virol. 1980 Dec;51(Pt 2):233-43. doi: 10.1099/0022-1317-51-2-233.
Latent infections have been established in cervical dorsal root ganglia of Balb/c mice following peripheral inoculation of ts mutants of HSV-1. Activation of the mutant LS2 at the non-permissive temperature in vitro by culture of excised ganglia, or in vivo by neurosurgery has allowed the unambiguous identification of the neuron as the site of latent infection. Evidence is presented which shows that activation of virus infection in latently infected ganglia by neurosurgery results in a reduction of the number of latent foci in that ganglion. One interpretation of this observation is that the productive infection which follows activation of latent virus in the neuron leads to the destruction of that cell.
在将单纯疱疹病毒1型（HSV-1）的温度敏感突变体经外周接种到Balb/c小鼠后，已在其颈背根神经节中建立了潜伏感染。通过切除神经节培养在非允许温度下体外激活突变体LS2，或通过神经外科手术在体内激活，已明确鉴定出神经元是潜伏感染的部位。本文提供的证据表明，神经外科手术激活潜伏感染神经节中的病毒感染会导致该神经节中潜伏病灶数量减少。对这一观察结果的一种解释是，神经元中潜伏病毒激活后发生的增殖性感染会导致该细胞的破坏。
