Schuster Randi M, Cather Corinne, Pachas Gladys N, Zhang Haiyue, Cieslak Kristina M, Hoeppner Susanne S, Schoenfeld David, Evins A Eden
Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
Addict Behav. 2017 Aug;71:89-95. doi: 10.1016/j.addbeh.2017.02.028. Epub 2017 Feb 24.
The estimated mortality gap between those with and without serious mental illness (SMI) is increasing, now estimated at 28years, which is largely due to smoking-related diseases.
We sought to identify predictors of 14-day continuous abstinence in stable outpatient smokers with SMI.
Adult smokers with schizophrenia spectrum (n=130) or bipolar disorder (n=23) were enrolled in a 12-week course of varenicline and cognitive-behavioral therapy for smoking cessation.
Independent predictors of abstinence included reduction in withdrawal symptoms prior to the quit day, fewer cigarettes smoked per day at baseline, better baseline attention, remitted alcohol dependence, and lower expectation of peer support to aid quitting.
Interventions that consider these targets may improve smoking cessation outcomes in those with SMI.
患有和未患有严重精神疾病（SMI）者之间的估计死亡率差距正在扩大，目前估计为28年，这在很大程度上归因于与吸烟相关的疾病。
我们试图确定患有SMI的稳定门诊吸烟者持续14天戒烟的预测因素。
患有精神分裂症谱系障碍（n = 130）或双相情感障碍（n = 23）的成年吸烟者参加了为期12周的伐尼克兰和认知行为疗法戒烟课程。
戒烟的独立预测因素包括戒烟日前戒断症状的减轻、基线时每天吸烟量减少、基线时注意力更好、酒精依赖缓解以及对同伴支持戒烟的期望较低。
考虑这些目标的干预措施可能会改善患有SMI者的戒烟效果。
