Song Tongxing, Yang Yang, Zhou Yuanfei, Wei Hongkui, Peng Jian
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Cell Mol Life Sci. 2017 Aug;74(15):2723-2733. doi: 10.1007/s00018-017-2492-2. Epub 2017 Mar 11.
It is well known that adipose tissue has a critical role in the development of obesity and metabolic diseases and that adipose tissue acts as an endocrine organ to regulate lipid and glucose metabolism. Accumulating in the adipose tissue, fatty acids serve as a primary source of essential nutrients and act on intracellular and cell surface receptors to regulate biological events. G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin resistance. In this review, we summarize recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. We offer a new perspective by comparing the different roles in a variety of homeostatic processes from adipogenic development to adipocyte metabolism, and we also discuss the effects of natural and synthetic agonists that may be potential agents for the treatment of metabolic diseases.
众所周知，脂肪组织在肥胖和代谢性疾病的发展中起着关键作用，并且脂肪组织作为一个内分泌器官来调节脂质和葡萄糖代谢。脂肪酸在脂肪组织中积累，作为必需营养素的主要来源，并作用于细胞内和细胞表面受体以调节生物学事件。G蛋白偶联受体120（GPR120）因其参与脂肪生成、炎症、葡萄糖摄取和胰岛素抵抗的调节，成为治疗肥胖相关代谢紊乱的一个有前景的靶点。在这篇综述中，我们总结了关于GPR120在脂肪组织（包括白色和棕色脂肪细胞）中的全身作用的最新研究和进展。我们通过比较从脂肪生成发育到脂肪细胞代谢等各种稳态过程中的不同作用，提供了一个新的视角，并且我们还讨论了天然和合成激动剂的作用，它们可能是治疗代谢性疾病的潜在药物。
