2016年的脂肪组织：对脂肪组织生物学认识的进展
Adipose tissue in 2016: Advances in the understanding of adipose tissue biology.
作者信息
Kajimura Shingo
机构信息
University of California, San Francisco, UCSF Diabetes Center, Department of Cell and Tissue Biology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, Box 0669, San Francisco, California 94143, USA.
出版信息
Nat Rev Endocrinol. 2017 Feb;13(2):69-70. doi: 10.1038/nrendo.2016.211. Epub 2017 Jan 4.
Abstract
Adipose tissues have a central role in energy homeostasis, as they secrete adipokines and regulate energy storage and dissipation. Novel adipokines from white, brown and beige adipocytes have been identified in 2016. Identifying the specific receptors for each adipokine is pivotal for developing greater insights into the fat-derived signalling pathways that regulate energy homeostasis.
摘要
脂肪组织在能量平衡中起着核心作用，因为它们分泌脂肪因子并调节能量的储存和消耗。2016年，人们在白色、棕色和米色脂肪细胞中发现了新型脂肪因子。确定每种脂肪因子的特异性受体对于更深入了解调节能量平衡的脂肪衍生信号通路至关重要。
相似文献
1
Adipose tissue in 2016: Advances in the understanding of adipose tissue biology.2016年的脂肪组织：对脂肪组织生物学认识的进展
Nat Rev Endocrinol. 2017 Feb;13(2):69-70. doi: 10.1038/nrendo.2016.211. Epub 2017 Jan 4.
2
Medicine. Wnt fans the flames in obesity.医学。Wnt在肥胖症中煽风点火。
Science. 2010 Jul 23;329(5990):397-8. doi: 10.1126/science.1193404.
3
Cardiotrophin-1 Regulates Adipokine Production in 3T3-L1 Adipocytes and Adipose Tissue From Obese Mice.心肌营养素-1调节3T3-L1脂肪细胞和肥胖小鼠脂肪组织中脂肪因子的产生。
J Cell Physiol. 2017 Sep;232(9):2469-2477. doi: 10.1002/jcp.25590. Epub 2017 Apr 10.
4
Adipocyte-derived hormones, cytokines, and mediators.脂肪细胞衍生的激素、细胞因子和介质。
Endocrine. 2006 Feb;29(1):81-90. doi: 10.1385/endo:29:1:81.
5
The many secret lives of adipocytes: implications for diabetes.脂肪细胞的多重秘密生活：对糖尿病的影响。
Diabetologia. 2019 Feb;62(2):223-232. doi: 10.1007/s00125-018-4777-x. Epub 2018 Nov 21.
6
Energy Regulation Mechanism and Therapeutic Potential of Asprosin.胰高血糖素原样肽-3 及其受体激动剂在多囊卵巢综合征治疗中的作用
Diabetes. 2020 Apr;69(4):559-566. doi: 10.2337/dbi19-0009.
7
[The importance of adipose tissue for development of obesity and diabetes mellitus type 2].[脂肪组织在肥胖症和2型糖尿病发生发展中的重要性]
Tidsskr Nor Laegeforen. 2003 Feb 6;123(3):311-4.
8
Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity.在人和鼠的脂肪组织中鉴定出 nesfatin-1：一种新型的脂肪组织特异性脂肪因子，在肥胖症中水平升高。
Endocrinology. 2010 Jul;151(7):3169-80. doi: 10.1210/en.2009-1358. Epub 2010 Apr 28.
9
Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.脂肪抑制素是一种新型脂肪因子，在脂肪组织和大脑中的表达与介素不同。
CNS Neurosci Ther. 2014 Apr;20(4):344-54. doi: 10.1111/cns.12219. Epub 2014 Jan 7.
10
Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism.重新审视脂肪细胞：能量代谢调节中细胞因子信号整合的模型。
Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E691-714. doi: 10.1152/ajpendo.00297.2015. Epub 2015 Sep 1.
引用本文的文献
1
Advancing Soft Tissue Reconstruction with a Ready-to-Use Human Adipose Allograft.使用即用型人同种异体脂肪移植推进软组织重建。
Bioengineering (Basel). 2025 Jun 4;12(6):612. doi: 10.3390/bioengineering12060612.
2
DESIGNER FAT CELLS: ADIPOGENIC DIFFERENTIATION OF CRISPR-CAS9 GENOME-ENGINEERED INDUCED PLURIPOTENT STEM CELLS.设计脂肪细胞：CRISPR-CAS9基因组工程化诱导多能干细胞的脂肪生成分化
Eur Cell Mater. 2023 Jul-Dec;46:171-194. doi: 10.22203/eCM.v046a09. Epub 2023 Dec 29.
3
Mild-photothermal and nanocatalytic therapy for obesity and associated diseases.温和光热和纳米催化疗法治疗肥胖及相关疾病。
Theranostics. 2024 Sep 3;14(14):5608-5620. doi: 10.7150/thno.99948. eCollection 2024.
4
Development of a mix-and-read assay for human asprosin using antibody-oligonucleotide probes and thermofluorimetric analysis.使用抗体-寡核苷酸探针和热荧光分析技术开发人嗜蛋白原混合读取检测法。
Anal Methods. 2024 Sep 12;16(35):6057-6063. doi: 10.1039/d3ay01175e.
5
White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models.在临床前模型中，皮下脂肪组织中的白色脂肪细胞需要 KLF15 来维持。
J Clin Invest. 2024 Jul 1;134(13):e172360. doi: 10.1172/JCI172360.
6
Interactions between age, sex and visceral adipose tissue on brain ageing.年龄、性别与内脏脂肪组织对大脑老化的相互影响。
Diabetes Obes Metab. 2024 Sep;26(9):3821-3829. doi: 10.1111/dom.15727. Epub 2024 Jun 20.
7
Asprosin contributes to pathogenesis of obesity by adipocyte mitophagy induction to inhibit white adipose browning in mice.人视黄醇结合蛋白 4 通过诱导脂肪细胞自噬抑制白色脂肪棕色化参与肥胖的发病机制。
Int J Obes (Lond). 2024 Jul;48(7):913-922. doi: 10.1038/s41366-024-01495-6. Epub 2024 Feb 19.
8
Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens.超越能量平衡调节：脂肪组织在宿主防御病原体中的被低估作用。
Front Immunol. 2023 Mar 2;14:1083191. doi: 10.3389/fimmu.2023.1083191. eCollection 2023.
9
Adipose Tissue Extracellular Matrix Remodeling in Response to Dietary Patterns and Exercise: Molecular Landscape, Mechanistic Insights, and Therapeutic Approaches.脂肪组织细胞外基质对饮食模式和运动的重塑：分子图景、机制见解及治疗方法
Biology (Basel). 2022 May 17;11(5):765. doi: 10.3390/biology11050765.
10
Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview.白色脂肪细胞分化早期的调控机制：概述。
Cell Mol Life Sci. 2022 Feb 20;79(3):139. doi: 10.1007/s00018-022-04169-6.
本文引用的文献
1
Brown adipose tissue as a secretory organ.棕色脂肪组织作为一个分泌器官。
Nat Rev Endocrinol. 2017 Jan;13(1):26-35. doi: 10.1038/nrendo.2016.136. Epub 2016 Sep 12.
2
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.分泌酶PM20D1调节线粒体的脂化氨基酸解偶联剂。
Cell. 2016 Jul 14;166(2):424-435. doi: 10.1016/j.cell.2016.05.071. Epub 2016 Jun 30.
3
Asprosin, a Fasting-Induced Glucogenic Protein Hormone.阿朴脂蛋白，一种禁食诱导的生糖蛋白激素。
Cell. 2016 Apr 21;165(3):566-79. doi: 10.1016/j.cell.2016.02.063. Epub 2016 Apr 14.
4
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.一种分泌型Slit2片段调节脂肪组织产热和代谢功能。
Cell Metab. 2016 Mar 8;23(3):454-66. doi: 10.1016/j.cmet.2016.01.008. Epub 2016 Feb 11.
5
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.人类“亮/米色”脂肪细胞由毛细血管网络发育而来，将其植入可改善小鼠的代谢稳态。
Nat Med. 2016 Mar;22(3):312-8. doi: 10.1038/nm.4031. Epub 2016 Jan 25.
6
Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function.用于研究冷诱导米色祖细胞以及米色脂肪细胞形成和功能的小鼠品系。
Nat Commun. 2016 Jan 5;7:10184. doi: 10.1038/ncomms10184.
7
Brown and Beige Fat: Physiological Roles beyond Heat Generation.棕色脂肪和米色脂肪：产热之外的生理作用
Cell Metab. 2015 Oct 6;22(4):546-59. doi: 10.1016/j.cmet.2015.09.007.
8
Genetic and functional characterization of clonally derived adult human brown adipocytes.克隆衍生的成人人类棕色脂肪细胞的遗传与功能特征分析
Nat Med. 2015 Apr;21(4):389-94. doi: 10.1038/nm.3819. Epub 2015 Mar 16.
9
Leptin therapy gains FDA approval.瘦素疗法获得美国食品药品监督管理局（FDA）批准。
Nat Biotechnol. 2014 Apr;32(4):300-2. doi: 10.1038/nbt0414-300b.
10
Functional brown adipose tissue in healthy adults.健康成年人中的功能性棕色脂肪组织。
N Engl J Med. 2009 Apr 9;360(15):1518-25. doi: 10.1056/NEJMoa0808949.
Zotero 插件