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小鼠中卵和化学致癌物诱导膀胱癌前病变的发生

Development of Urinary Bladder Pre-Neoplasia by Eggs and Chemical Carcinogen in Mice.

作者信息

Chala Bayissa, Choi Min-Ho, Moon Kyung Chul, Kim Hyung Suk, Kwak Cheol, Hong Sung-Tae

机构信息

Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul 03080, Korea.

Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea.

出版信息

Korean J Parasitol. 2017 Feb;55(1):21-29. doi: 10.3347/kjp.2017.55.1.21. Epub 2017 Feb 28.

DOI:10.3347/kjp.2017.55.1.21
PMID:28285503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5365267/
Abstract

is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting eggs into the bladder wall and introduction of chemical carcinogens. Histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. Squamous metaplasia was observed in the eggs+NDMA group at week 12 but not in other groups. Immunohistochemistry revealed significantly high expression of in urothelial epithelial cells of the eggs+BBN group at week 20. The qRT-PCR showed high expression of gene in eggs group at week 4 and eggs+BBN group at week 20. and showed contrasting expression in eggs+BBN group. Such inverse expression of and may indicate epithelial mesenchymal transition in the UB tissue. In conclusion, eggs and nitrosamines may transform UB cells into squamous metaplasia and dysplasia in correlation with increased expression of Ki-67. Marked decrease in and increase in and expressions may support the transformation. The present study introduces a promising modified animal model for UB cancer study using eggs.

摘要

是人类膀胱（UB）的生物致癌物。本研究通过将鸡蛋注入膀胱壁并引入化学致癌物来研究膀胱癌小鼠模型的建立。组织病理学结果显示从轻度增生到上皮空泡样改变，以及高级别发育异常。在第12周时，鸡蛋+亚硝基二甲胺（NDMA）组观察到鳞状化生，而其他组未观察到。免疫组织化学显示，在第20周时，鸡蛋+N-丁基-N-（4-羟基丁基）亚硝胺（BBN）组的尿路上皮细胞中该蛋白表达显著升高。定量逆转录聚合酶链反应（qRT-PCR）显示，在第4周时鸡蛋组以及第20周时鸡蛋+BBN组中该基因表达升高。在鸡蛋+BBN组中，两者表现出相反的表达。 和 的这种反向表达可能表明膀胱组织中的上皮-间质转化。总之，鸡蛋和亚硝胺可能使膀胱细胞转化为鳞状化生和发育异常，这与Ki-67表达增加相关。 和 表达的显著降低以及 和 表达的增加可能支持这种转化。本研究引入了一种有前景的使用鸡蛋的改良动物模型用于膀胱癌研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/a4cdb3ba757d/kjp-55-1-21f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/800556ae06f7/kjp-55-1-21f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/39312909d64d/kjp-55-1-21f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/c5eb31279096/kjp-55-1-21f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/a4cdb3ba757d/kjp-55-1-21f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/800556ae06f7/kjp-55-1-21f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/1eeee82a8108/kjp-55-1-21f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/8aaae64b7a82/kjp-55-1-21f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/92abf3fd7e47/kjp-55-1-21f4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/c5eb31279096/kjp-55-1-21f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b5/5365267/a4cdb3ba757d/kjp-55-1-21f7.jpg

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