Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Department of Zootechnics, University of Trás-os-Montes and Alto Douro, 911 Vila Real, Portugal ; Center for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, Portugal ; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Iran J Basic Med Sci. 2014 Feb;17(2):145-8.
OBJECTIVE(S): Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice.
The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks.
Animals from groups BBN+GT and BBN only developed preneoplastic lesions.
We did not observe any effects by GT infusion administration on urinary bladder cancer development.
绿茶（GT）是全球最受欢迎的饮料之一，其对健康的有益影响已得到证实。最近的研究表明，GT 可能有助于降低癌症风险和进展。本研究旨在评估全 GT 对雄性和雌性 ICR 小鼠膀胱化学致癌作用的影响。
采用分光光度法对 GT 进行表征。通过灌胃在 10 周内用 N-丁基-N-（4-羟丁基）亚硝胺（BBN）诱导膀胱病变，并在 20 周内自由提供全 GT（0.5%）。
BBN+GT 组和 BBN 组的动物均发生了癌前病变。
我们没有观察到 GT 输注给药对膀胱癌发展的任何影响。
