Gast M J, Rigg L A, Amyx C L, Kessler G
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
J Perinat Med. 1987;15(3):263-9. doi: 10.1515/jpme.1987.15.3.263.
Angiotensin-converting enzyme occupies a central position in the dynamics of the renin-angiotensin system. We prospectively studied serum angiotensin-converting enzyme activity in 112 women at various stages of pregnancy and in the postpartum period because converting enzyme levels have not been well documented in pregnant women with medical disorders which might be expected to influence intravascular volume or blood pressure. Enzyme activity is lower during pregnancy than it is in the same population at 6 weeks postpartum. Levels of serum angiotensin converting enzyme activity remain relatively stable during gestation but drop during the immediate postpartum period. Diabetes, chronic hypertension, and pregnancy induced hypertension fo not markedly change serum angiotensin converting enzyme activity.
血管紧张素转换酶在肾素-血管紧张素系统的动态变化中占据核心地位。我们前瞻性地研究了112名处于妊娠各阶段及产后的女性的血清血管紧张素转换酶活性，因为在可能影响血管内容量或血压的内科疾病孕妇中，转换酶水平尚未得到充分记录。孕期的酶活性低于产后6周同一人群的酶活性。血清血管紧张素转换酶活性水平在妊娠期相对稳定，但在产后即刻会下降。糖尿病、慢性高血压和妊娠高血压综合征不会显著改变血清血管紧张素转换酶活性。
