Murayama Y, Noguchi A, Takenaka O
Primate Research Institute, Kyoto University, Aichi, Japan.
J Med Primatol. 1987;16(6):373-87.
Responses of peripheral blood mononuclear cells to phytohemagglutinin-P (PHA-P), concanavalin-A (ConA), and pokeweed mitogen (PWM) were compared in man and Japanese monkeys. Both CD8+ and CD8- T subsets showed greater responses to ConA than to PHA-P in the Japanese monkey. Addition of macrophages to each T subset produced more effective augmentation of ConA response in the Japanese monkey than in man, and ConA induced more interleukin-2-receptor-positive blast cells than PHA-P did in Japanese monkeys.
比较了人类和日本猕猴外周血单个核细胞对植物血凝素-P（PHA-P）、刀豆蛋白A（ConA）和商陆有丝分裂原（PWM）的反应。在日本猕猴中，CD8 +和CD8 - T细胞亚群对ConA的反应均强于对PHA-P的反应。在日本猕猴中，向每个T细胞亚群添加巨噬细胞对ConA反应的增强作用比在人类中更有效，并且在日本猕猴中，ConA诱导产生的白细胞介素-2受体阳性母细胞比PHA-P诱导产生的更多。
