Xu Shun, Cheng Jie, Cai Meng-Yun, Liang Li-Li, Cen Jin-Ming, Yang Xi-Li, Chen Can, Liu Xinguang, Xiong Xing-Dong
Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China.
Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Department of Clinical Laboratory, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Dis Markers. 2017;2017:9463272. doi: 10.1155/2017/9463272. Epub 2017 Feb 14.
has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI). Nonetheless, the role of the polymorphisms on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs in gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact of polymorphisms on individual susceptibility to MI. Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1.03-1.66, and = 0.029) and CC genotype (OR = 1.84, 95% CI = 1.11-3.06, and = 0.018) of rs1050998 were associated with increased MI risk; and C allele (OR = 0.77, 95% CI = 0.60-0.98, and = 0.036) of rs8123 exhibited decreased MI risk, while the other two tagSNPs had no significant effect. Consistently, the haplotype rs2304973T-rs1050998C-rs3744700G-rs8123A containing the C allele of rs1050998 and A allele of rs8123 exhibited elevated MI risk (OR = 1.41, 95% CI = 1.02-1.96, and = 0.037). Further stratified analysis unveiled a more apparent association with MI risk among younger subjects (≤60 years old). Taken together, our results provided the first evidence that polymorphisms significantly impacted MI risk in Chinese subjects.
已证明其参与动脉粥样硬化和心肌梗死（MI）的发生发展。然而，该基因多态性在MI发病机制中的作用尚待阐明。我们对275例MI患者和670例对照者的该基因中的4个标签单核苷酸多态性（tagSNPs）（rs2304973、rs1050998、rs3744700和rs8123）进行基因分型，旨在探究该基因多态性对个体MI易感性的影响。多因素逻辑回归分析显示，rs1050998的C等位基因（OR = 1.31，95%CI = 1.03 - 1.66，P = 0.029）和CC基因型（OR = 1.84，95%CI = 1.11 - 3.06，P = 0.018）与MI风险增加相关；rs8123的C等位基因（OR = 0.77，95%CI = 0.60 - 0.98，P = 0.036）表现出MI风险降低，而其他两个标签单核苷酸多态性无显著影响。同样，包含rs1050998的C等位基因和rs8123的A等位基因的单倍型rs2304973T - rs1050998C - rs3744700G - rs8123A表现出MI风险升高（OR = 1.41，95%CI = 1.02 - 1.96，P = 0.037）。进一步的分层分析揭示了在较年轻受试者（≤60岁）中与MI风险的关联更为明显。综上所述，我们的结果首次证明该基因多态性显著影响中国受试者的MI风险。
