Chen Yeong-Jang, Pao Jwo-Luen, Chen Chiang Sang, Chen Yu-Chun, Chang Chun-Chien, Hung Fang-Ming, Chang Chih-Hung
Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.
Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, 10002 Taiwan.
J Med Biol Eng. 2017;37(1):85-93. doi: 10.1007/s40846-016-0203-3. Epub 2017 Jan 19.
Autogenous bone grafting, used to repair bone defects, is limited and the donor site can experience complications. Compared to autogenous bone graft, artificial bones have different porosity, which might make them suitable alternatives to bone grafts. Here, two porous biphasic calcium phosphate bone substitutes, namely Bicera™ and Triosite™, are used in an animal study and clinical practice to find a suitable porosity for implantation. Bicera™ and Triosite™ consist of 60 wt% hydroxyapatite and 40 wt% β-tricalcium phosphate, with the porosity of Bicera™ (82%) being higher than that of Triosite™ (70%). In the animal study, the implantation procedure was carried out on twenty-four female New Zealand rabbits. 12 weeks after implantation, the new bones were well infiltrated into the Bicera™ and Triosite™ bone grafts. In the clinical study, patients with comminuted fracture, fracture nonunion, or arthrodesis were included in the study of bone substitution with Bicera™. 27 patients underwent fracture fixation treatment. Bone healing of 22.22% (6/27) of patients happened within 3 months after the surgery, and that of 66.67% (18/27) of patients happened within 6 months. These results reveal that Bicera™ has good incorporation with host bone, and that new bone is able to grow within the porous structure, giving it high potential in the treatment of bone defects.
用于修复骨缺损的自体骨移植存在局限性，且供体部位可能会出现并发症。与自体骨移植相比，人工骨具有不同的孔隙率，这可能使它们成为骨移植的合适替代品。在此，两种多孔双相磷酸钙骨替代物，即Bicera™和Triosite™，被用于一项动物研究和临床实践中，以寻找适合植入的孔隙率。Bicera™和Triosite™均由60 wt%的羟基磷灰石和40 wt%的β-磷酸三钙组成，Bicera™的孔隙率（82%）高于Triosite™（70%）。在动物研究中，对24只雌性新西兰兔进行了植入手术。植入12周后，新骨很好地长入了Bicera™和Triosite™骨移植体中。在临床研究中，粉碎性骨折、骨折不愈合或关节融合的患者被纳入使用Bicera™进行骨替代的研究。27例患者接受了骨折固定治疗。22.22%（6/27）的患者在术后3个月内实现了骨愈合，66.67%（18/27）的患者在6个月内实现了骨愈合。这些结果表明，Bicera™与宿主骨具有良好的融合性，并且新骨能够在多孔结构内生长，使其在治疗骨缺损方面具有很高的潜力。
