Jalili Mahdi, Salehzadeh-Yazdi Ali, Mohammadi Saeed, Yaghmaie Marjan, Ghavamzadeh Ardeshir, Alimoghaddam Kamran
Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany.
Int J Hematol Oncol Stem Cell Res. 2017 Jan 1;11(1):1-12.
Acute promyelocytic leukemia (APL) is a unique subtype of acute leukemia. APL is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in APL patient management. One issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood. In this study, we performed a meta-analysis of gene expression profiles derived from microarray experiments and explored the background of disease by functional and pathway analysis. Our analysis revealed a gene signature with 406 genes that are up or down-regulated in APL. The pathway analysis determined that MAPK pathway and its involved elements such as JUN gene and AP-1 play important roles in APL pathogenesis along with insulin-like growth factor-binding protein-7. The results of this meta-analysis could be useful for developing more effective therapy strategies and new targets for diagnosis and drugs.
急性早幼粒细胞白血病（APL）是急性白血病的一种独特亚型。APL是一种可治愈的疾病；然而，耐药性、早期死亡率、疾病复发和治疗相关并发症仍是APL患者管理中的挑战。这些挑战背后的一个问题是对该疾病的分子机制了解不足。在本研究中，我们对来自微阵列实验的基因表达谱进行了荟萃分析，并通过功能和通路分析探索了疾病背景。我们的分析揭示了一个由406个在APL中上调或下调的基因组成的基因特征。通路分析确定，丝裂原活化蛋白激酶（MAPK）通路及其相关元件如JUN基因和活化蛋白-1（AP-1）以及胰岛素样生长因子结合蛋白-7在APL发病机制中起重要作用。该荟萃分析的结果可能有助于制定更有效的治疗策略以及诊断和药物的新靶点。
