LeMoult Joelle, Kircanski Katharina, Prasad Gautam, Gotlib Ian H
Stanford University.
University of Southern California.
Clin Psychol Sci. 2017 Jan;5(1):174-181. doi: 10.1177/2167702616654898. Epub 2016 Oct 19.
Most individuals who develop Major Depressive Disorder (MDD) will experience a recurrent depressive episode; we know little, however, about cognitive mechanisms that increase the likelihood of recurrence. In the current study we examined whether negatively biased self-referential processing, negative life events, baseline depressive symptoms, and psychotropic medication use predicted the onset of a subsequent depressive episode in a longitudinal study of women with a history of recurrent MDD. Higher levels of depressive symptoms at baseline predicted experiencing a greater number of negative life events which, in turn, tended to predict recurrence of depression. Importantly, after accounting for other associations, negatively biased self-referential processing contributed unique variance to the likelihood of experiencing a depressive episode over the next three years. Thus, negatively biased self-referential processing appears to be a significant risk factor for the recurrence of depressive episodes and may be an important target for interventions aimed at preventing future episodes.
大多数患重度抑郁症（MDD）的个体将会经历复发性抑郁发作；然而，我们对增加复发可能性的认知机制知之甚少。在当前的研究中，我们在一项针对有复发性MDD病史女性的纵向研究中，检验了负性偏向的自我参照加工、负性生活事件、基线抑郁症状以及精神药物使用是否能预测随后抑郁发作的发生。基线时较高水平的抑郁症状预示着会经历更多的负性生活事件，而这反过来又往往预示着抑郁症的复发。重要的是，在考虑了其他关联因素后，负性偏向的自我参照加工对未来三年经历抑郁发作的可能性有独特的预测作用。因此，负性偏向的自我参照加工似乎是抑郁发作复发的一个重要风险因素，可能是旨在预防未来发作的干预措施的一个重要靶点。
